Madame Web is a mutant that possesses psychic sensory powers including telepathy, clairvoyance, prescience, and the ability to sense the presence of psionic powers in others. She can also perform psychic surgery and appear to others in spirit (astral) form. She has a gifted intellect.

When dying she displayed the ability to transfer her mutation to another individual, Julia Carpenter, as well as her blindness.[volume & issue needed]

Madame Web was a victim of myasthenia gravis, a disorder of neuromuscular junction transmission. As a result, she was an invalid entirely dependent on external life support for survival. This is no longer the case as she was cured of the condition some time ago. She is also blind. Madame Web is cybernetically linked to a spider-web-like life support chair which attends to all of her bodily needs.
base figure X-23
Wasp head Apoxie carving
legs from the 90s Spider-man animated series
Apoxie work and full repint